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Researchers develop new mouse model to study Zika virus and find potential treatments
Published on November 18, 2016 at 8:04 PM
Researchers have developed a new mouse model that could be used in Zika research to better understand the virus and find new treatments, according to a study published in PLOS Pathogens.
A person infected with Zika virus usually has no symptoms or only has mild ones. However, in recent outbreaks, the virus has been linked to increased rates of neurological disorders and birth defects. There is an urgent need for better animal models for laboratory research to study the Zika virus and potential treatments.
Previous studies have shown that young mice with specific immune system defects are susceptible to Zika infection. However, studying Zika in mice with compromised immune systems could skew results. Now, researchers at the U.S. Food and Drug Administration's Center for Drug Evaluation and Research demonstrate that mice with functioning immune systems can be successfully infected with Zika.
"This new mouse model developed by the FDA could be used to explore Zika virus' pathology and potentially help to develop treatments or vaccines," says Mohanraj Manangeeswaran, senior staff fellow in the FDA's Office of Pharmaceutical Quality. "Because the mice used in this model have immune systems that allow them to survive initial infection, they could be particularly helpful for studying the long-term effects of Zika virus infection."
The new mouse model employs a mouse strain called C57BL6, which is commonly used in disease research. The scientists infected 1-day-old C57BL6 mice with Zika virus and found that they develop symptoms of neurological disease, such as unsteady gait and seizures that gradually fade over two weeks.
The researchers compared their new mouse model with young mice that have immune system defects and are known to die several days after Zika infection. They found significant differences in disease progression, immune system response, and neurological effects between the two models.
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Science Snippet: Skin Mites
The top photo shows an adult human skin mite as seen with the scanning electron microscope; note the stubby legs. The bottom image is a depiction of mites on the surface of human skin, as well as in the follicle of an eyelash.
“You Almost Certainly Have Mites On Your Face” was the title of a National Geographic article that surely discouraged anyone who read it. Mites belong to the same group (Class Arachnida) as spiders, daddy longlegs and scorpions. Probably you are more fearful of spiders than the mites that live at the bases of your eyelashes or in your sebaceous skin glands. Since your mites are only 0.1-0.4 mm long, you don’t even know they are there. Out of sight, out of mind should be our mantra. The genus name of our mites is Demodex, which comes from Greek words that mean “boring worm.” Mites are rare on babies, more common on teenagers, and universal in adults. They have eight legs and a long abdomen that extends up to the surface of the skin. They feed on cellular debris and fatty secretions and most of us consider them rather nasty because they don’t poop. Their excreta continues to fill their abdomen until it swells and finally bursts, with the contents released onto your skin. You never know it happens! Remember: out of sight, out of mind. You don’t fuss about the bacteria in your gut, so get used to living with skin mites. (phenomena.nationralgeographicm20127; “Meet Your Mites,” robdunnlabmprojectsmeet-your-mites; news-medicalhealth)
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