STERLING, Va., June 13, 2007 (major NEWSWIRE) -- Evergreen techniques will latest on the HP utility Universe in Las Vegas, June 18-21, 2007, addressing themes that range from carrier catalog construction, to combining HP applied sciences with ITIL consulting processes, to constructing the enterprise value of ITIL. particulars on the conference may also be found at http://www.HP.com/go/softwareuniverse
Evergreen programs, a leading IT consulting company, is wonderful among different HP companions in that it presents not most effective technical advantage in HP provider management (legacy Peregrine) and BTO (Mercury) functions, however that its consultants are also veteran ITIL method Consulting consultants. an overview of Evergreen's HP functions can also be discovered at http://www.evergreensys.com/applied sciences/HPopenview/. Evergreen consultants might be available for dialogue at HP application Universe in sales space 309.
Consulting practice supervisor Tony Iannetta should be discussing all facets of service catalog construction, including the add-ons of a comprehensive carrier catalog mannequin, as well as Evergreen's methodology for 'leap-beginning' provider catalog development. The HP service Catalog module as an integrated element of ITSM will be lined as smartly. be trained more about provider catalog through downloading Evergreen's standard white paper 'eight Steps to service Catalog building' at http://www.evergreensys.com/downloads/servicecatalog/.
Evergreen's VP of business construction, Joe Koester, will present actual-world examples of the usage of existing HP ServiceCenter, AssetCenter and BTO (Mercury) applied sciences to mix ITIL optimum practices with HP most fulfilling-of-breed infrastructure know-how. For more assistance on this subject matter discuss with http://www.evergreensys.com/applied sciences/.
Don Casson, Evergreen's CEO, will focus on the business case for ITIL, focusing on ITIL now not best as a technique, however additionally as a transparent framework for streamlining IT to obtain alignment with company desires. down load Don's complete white paper on setting up the company price of ITIL at http://www.evergreensys.com/downloads/businessvalueofitil/.
Evergreen has a song record of figuring out and aiding legacy HP service management(tm) (Peregrine) purposes, together with ServiceCenter and AssetCenter, as well as a history in BTO (Mercury) technologies. This tune listing, combined with ten years of adventure with ITIL, ITAM and IT technique development consultation, sets Evergreen aside on the planet of HP know-how partners.
Leaders in coverage, finance, healthcare and retail rely on Evergreen to address present day primary company challenges, including making ITIL, ITAM and ITSM operable; understanding and organizing IT property for improved planning and execution; constructing computerized, streamlined compliance strategies; and maximizing advantage via trade, Configuration and Asset management.Evergreen systems, Inc. Amy Mergler, company construction Administrator 571-262-0977 http://www.evergreensys.com
Sterling, Virginia, u.s.
http://www.evergreensys.comEvergreen methods, Inc. Amy Mergler, company building Administrator 571-262-0977 http://www.evergreensys.com
The product integration comes three months after HP accomplished its US$425 million acquisition of Peregrine last December."inform me we might not be round in three to four years? I suppose the reverse should be proper." -- David GeeHP software Asia-Pacific/Japan
Peregrine's AssetCenter, combined with HP's OpenView carrier Desk, will supply agencies with greater perception and handle over their IT belongings including software, workstations and servers, talked about Todd DeLaughter, vice chairman and time-honored supervisor of HP's OpenView business unit. He turned into speakme on the HP application forum in Sydney, the first such adventure held in the Asia-Pacific vicinity.
DeLaughter said the mixing underpins HP's active Configuration administration Database (CMDB) strategy. CMDB is used to shop statistics in regards to the state of a company's IT belongings, together with these generated through competing commercial enterprise administration software, comparable to system mistakes and utility adjustments in addition to company facts on personnel and enterprise units. It additionally shows the relationship amongst company assets.
Todd explained that intelligence aspects built into HP's active CMDB permit organizations to consolidate disparate device management records from distinct sources. CMDB will then synchronize such statistics and supply organizations with an overview of their IT operations, he introduced.
In its annual tech developments report closing December, however, Gartner had estimated that by using 2008, most effective IBM and CA would stay on the listing of good four administration software vendors, which these days comprises HP and BMC software.
The analyst company didn't identify the carriers that would fill the void, nor did it say if its forecast had considered HP's Peregrine acquisition.
Gartner did say that HP can also lose its seat, not from having a weaker product, however on account of capabilities market challengers with equally deep pockets comparable to EMC, Symantec and Microsoft.
David Gee, vice president and generic manager of HP application Asia-Pacific and Japan, rebuffed the analyst's prediction, noting that the enterprise's OpenView international utility profits had improved 34 % year-on-year throughout the primary quarter this 12 months.
"Our growth in the distributed management software area in mature markets relatively an awful lot outstripped all and sundry," Gee instructed ZDNet Asia.
"there is comfortably no valid empirical information that backs up Gartner's assertions," he noted. "With Peregrine, the OpenView business is close to US$1 billion. inform me we won't be round in three to 4 years? I suppose the reverse should be authentic."
He noted that HP's application licensing revenues were growing one to 3 times greater than rivals BMC, CA and IBM. "The statistics communicate for themselves."
Gee is also unfazed about upcoming opponents, besides the fact that children he is preserving song of their plans.
"Microsoft has placed itself as a competitor in the management software house," he referred to. "within the small workgroup environment, they're going to have market presence. however the second you switch to a heterogeneous ambiance, their footprint is pretty minimal."
Symantec also has its hands full with its Veritas merger, so Gee doesn't see the security company as a competitor within the brief to medium term.
"EMC has got SMARTS (an experience automation and network methods management software dealer), however we do not see them as a competitor…even though it is one of the agencies we watch very carefully in terms of what their long-time period ambitions could be," he said.
in response to a separate document launched by way of Gartner in December closing 12 months, HP's Peregrine acquisition will add IT asset management capabilities that have been "sorely lacking" in HP's OpenView portfolio. The analysis company talked about that AssetCenter has one of the biggest asset management put in bases among firms global, with over 800 valued clientele on energetic renovation contracts.
Gartner referred to that the acquisition may well be HP's try and fill its product gaps, principally in provider desk application that provides helpdesk and service-degree management capabilities.
HP already has its personal carrier Desk 5.0 which became launched late ultimate 12 months, basically four years after the last essential unlock provider Desk 4.5.
Georg Bock, HP's director for product administration of OpenView solutions, told ZDNet Asia that the enterprise took longer to boost provider Desk 5.0 since the product contains a new architecture that underpins future OpenView products.
"It turned into a practise now not for the provider Desk product itself, but for the total OpenView portfolio," he noted.
however Gartner stated that the Peregrine acquisition has really, allowed HP to purchase market share within the IT service desk market--which the IT supplier became having problem building with its own products after decades of attempting.
With the buyout, HP has taken a leading position within the provider desk market, 2nd simplest to rival BMC, Gartner noted.
Matt Schvimmer, supervisor for methods and utility engineer at HP's OpenView business Unit, mentioned the company is committed to its plan to unveil in the subsequent two years, a hybrid carrier desk product so that it will comprise facets from both Peregrine ServiceCenter and HP OpenView service Desk.
Gee pointed out the acquisition has conveniently doubled HP's analysis and construction efforts in its carrier desk product. He told ZDNet: "With the skill and competencies that we picked up from Peregrine, we're assured of supplying on agenda."
Aaron Tan of ZDNet Asia mentioned from Sydney, Australia.
Exponentially becoming cells bought from the IGROV (ovarian cancer), Caco-2 (colon melanoma) and H226 (lung melanoma) mobilephone lines had been cultured in 4 ml of RPMI-1640 medium, and plated in 25 cm2 T-flasks (Corning Costar), at a density of 10 000 cells/flask. Hereafter, plates were incubated in a controlled ambiance at 37°C and ninety five% air per 5% CO2, and 24 h after the beginning of incubation, the medium changed into replaced by using medium containing SN-38 at final concentrations of one hundred pM (39.2 pg ml−1), 1.00 nM (392 pg ml−1), or 10.0 nM (3920 pg ml−1). These concentrations had been chosen as a result of they accurately simulated the median SN-38 plasma concentrations circulating in patients after 3 weeks, 10 days and a pair of days, respectively, after infusion of the usual dose of CPT-11 (350 mg m−2, given as a 90-min infusion as soon as every three weeks; see figure 1). As a control, flasks containing cells within the absence of SN-38 had been used. At 48-h intervals, and for a highest length of about 3 weeks (i.e., 500 h), the way of life medium became changed with sparkling medium to minimise probably confounding outcomes led to by way of instability of SN-38 via chemical instability. at the identical intervals, tradition flasks have been handled with trypsin for 30 min, and subsequently the mobile suspension turned into centrifuged for 2 min at 500 g (4°C). next, the supernatant changed into discarded, and the cells were re-suspended in 50 μl of buffer and counted in a Bürker-cellphone chamber. every experiment changed into repeated twice, with each counting performed in quadruplicate.figure 1
Plasma attention-time profiles of SN-38 in sufferers treated with a 90-min i.v. infusion of CPT-eleven (dose level 350 mg m−2).patients and treatment
We retrospectively studied statistics from patients collaborating to a lot of potential clinical trials on CPT-11 by which pharmacokinetic monitoring turned into involved; the total medical profiles are documented in other places (Kehrer et al, 2000, 2001a, 2002). All sufferers had a histologically or cytologically verified malignant solid tumour for which CPT-eleven changed into regarded to be a medicine option. An satisfactory haematopoietic (white blood telephone count number (WBC) ⩾3.0×109 l−1; absolute neutrophil count (ANC) ⩾1.5×109 l−1; and platelet count number (PLT) ⩾a hundred×109 l−1), hepatic and renal feature on the time of study entry become required. Eligibility standards additionally blanketed a global fitness organization performance fame of 0 or 1, and age between 18 and 70 years. earlier than analyze entry, written advised consent was obtained from all sufferers.
CPT-11 become offered by Aventis (Antony Cedex, France) as a hydrochloride trihydrate salt in vials containing 40 or a hundred mg, dissolved in d-sorbitol and a lactic acid-sodium hydroxide buffer device (pH 3.5–4.5) at a concentration of 20 mg ml−1. This solution was further diluted in 250 ml of sterile, isotonic sodium chloride, earlier than dosing. The drug changed into administered as a 90-min continuous intravenous infusion at a dose of 350 mg m−2, and every affected person bought prophylactic antiemetics including ondansetron (eight mg) or granisetron (1 mg) and dexamethasone (10 mg). in the first path of medication, patients didn't receive some other treatment common to intrude with CPT-eleven pharmacokinetics.Pharmacokinetic evaluation
Blood samples for pharmacokinetic evaluation were drawn from an indwelling cannula from the arm contrary to that used for drug infusion. These samples were amassed in glass tubes containing lithium heparin just before infusion, at 0.5, and 1.5 h (conclusion of infusion) throughout infusion, and at 10, 20, and 30 min, and 1, 1.5, 2, 4, 5, 8.5, 24, 32, 48, 56, one hundred ninety, 360, and 500 h after the end of infusion. Blood samples were instantly centrifuged at 3000 g for 10 min after collection to separate the blood cells and the plasma fraction, and were kept at −80°C except evaluation.
Concentrations of CPT-11 and its metabolite SN-38 were determined with the aid of reversed-phase excessive-performance liquid chromatography with fluorescence detection, as described in aspect in other places (De Bruijn et al, 1997). To examine SN-38 at low femtomole ranges, a more certain analytical formulation changed into used (De Bruijn et al, 1999). past pharmacokinetic findings showed that total drug degrees (i.e., the entire of lactone and carboxylate kinds) of CPT-eleven and SN-38 provided a constant and accurate reflection of the pharmacologically lively lactone awareness of both compounds with little variability (Sasaki et al, 1995). for this reason, it turned into concluded that complete drug monitoring of CPT-11 and SN-38 may serve as a suitable surrogate of the respective lactone varieties. For practical reasons, we only used complete drug forms for further evaluation. Plasma attention-time facts of CPT-11 and SN-38 have been fitted to a tri-exponential equation the use of the software equipment Siphar v4.0 (InnaPhase, Philadelphia, PA, country), based on up to now described considerations for mannequin discrimination (Sparreboom et al, 1998). Calculation of the area below the plasma attention-time curve (AUC) became in response to integration from the tri-exponential curve with extrapolation to infinity. Extrapolated AUC values of SN-38 were both in accordance with a fifty six-h (AUC56 h) or a 500-hour sampling-time period (AUC500 h).publicity-toxicity relationships
Haematological parameters of interest (i.e., those derived from ANC, WBC and PLT) had been determined earlier than CPT-eleven infusion and on a twice weekly basis all over the total pharmacokinetic sampling-time duration, to enable a pharmacokinetic/pharmacodynamic (PK/PD) contrast. The pharmacodynamic endpoint for institution of the PK/PD relationships became determined in two other ways. (i) First, just before the PK/PD evaluation, particular person toxicity records expressed as blood telephone counts were plotted for each affected person in a awareness vs time profile. The estimated area over these curves (AOCtox), as well as the enviornment under the curves (AUCtox), was calculated with the aid of the linear-trapezoid formula (determine 2). The ratio AOCtox/(AOCtox+AUCtox), called AOC, in which the denominator represents the area described through the pre-remedy toxicity cost times the highest pharmacokinetic sampling time, changed into hypothesised to be an easy and accurate function of drug-linked haematological toxicity (Gurney et al, 1998). (ii) 2d, drug-linked haematological toxicities were evaluated through the use of the nadir count, which changed into measured to assess the per cent decrease in haematopoietic cells as:figure 2
illustration of an ANC-time sample. The triangle represents the nadir count number. The horizontal line represents the baseline price of ANC.
To avoid confounding bias due to alterations in haematological information unrelated to medicine, patients showing excessive pre-infusion haematological numbers (i.e., with ANC>13.0×109/liter−1) have been excluded in these calculations. each of these two relative haematological-toxicity features have been geared up to the AUC of SN-38 the usage of a sigmoidal maximum impact (Emax) model, based on a modified Hill equation, as follows:
during this equation, E0 is the minimum discount viable, Emax is the highest response, CE50 is the AUC cost of SN-38 estimated to outcomes in 50% of the optimum response, and γ is the Hill regular, which describes the sigmoidicity of the curve (Holford and Sheiner, 1981).
Pharmacokinetic-pharmacodynamic evaluation became carried out the usage of the utility package Siphar v4.0, and weighted and prolonged least squares options were used to estimate model parameters. mannequin choice changed into guided by way of the decrease within the goal feature price (−2×log likelihood). The standards to assess the goodness of healthy of the fashions became according to: (i) computation of the coefficient of model, defined because the ratio of the common deviation computed using the variance-covariance matrix and the parameter cost, (ii) the Akaike counsel criterion, and (iii) the correlation coefficient and P-cost of the connection.Statistical considerations
All statistical calculations were performed using the number Cruncher Statistical gadget kit v5.X (J.L. Hintze, East Kaysville, UT, united states of america) and/or the Siphar kit. The stage of magnitude became set at P<0.05.restricted sampling models (LSMs)
patients were randomly entered in two corporations, a working towards-data set and a validation-data set containing up to 20 samples for every particular person affected person, as has been described earlier than (Mathijssen et al, 1999). A limited block randomisation changed into carried out as described elsewhere (Altman, 1991) to preserve the variety of sufferers close for each groups, and only one path of each affected person become taken to prevent bias because of potential cumulative consequences and to keep the observations unbiased.
Our goal become to predict the AUC of SN-38 thoroughly with a minimal number of samples (1 to three). additionally, these samples should be taken on the most effortless time-aspects for useful explanations. step one in the model building consisted of univariate linear-regression evaluation to assess the greatest single-pattern time features from the training information set. next, we performed a stepwise (forward) multivariate linear-regression analysis using the most fulfilling single sampling-time features to explain the association between SN-38 concentrations at numerous time elements and its corresponding AUC. The Pearson's coefficient (r), root mean-square error (RMSE), and mean-predictive error (MPE), which describe correlation, precision and bias, respectively, have been calculated to assess the most desirable LSMs. The usefulness of the fashions become evaluated within the working towards statistics set, by means of evaluating AUC values decided using the entire data with AUC values predicted by way of the LSMs.
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Alfresco [1 Certification Exam(s) ]
Altiris [3 Certification Exam(s) ]
American-College [2 Certification Exam(s) ]
Android [4 Certification Exam(s) ]
APC [2 Certification Exam(s) ]
APICS [1 Certification Exam(s) ]
Apple [69 Certification Exam(s) ]
Arizona-Education [1 Certification Exam(s) ]
ARM [1 Certification Exam(s) ]
Aruba [6 Certification Exam(s) ]
ASIS [2 Certification Exam(s) ]
ASQ [3 Certification Exam(s) ]
ASTQB [6 Certification Exam(s) ]
Autodesk [2 Certification Exam(s) ]
Avaya [85 Certification Exam(s) ]
Axis [1 Certification Exam(s) ]
Banking [1 Certification Exam(s) ]
BEA [5 Certification Exam(s) ]
BICSI [2 Certification Exam(s) ]
BlackBerry [17 Certification Exam(s) ]
BlueCoat [2 Certification Exam(s) ]
Business-Objects [11 Certification Exam(s) ]
Business-Tests [4 Certification Exam(s) ]
CA-Technologies [20 Certification Exam(s) ]
Certification-Board [9 Certification Exam(s) ]
Certiport [3 Certification Exam(s) ]
CheckPoint [31 Certification Exam(s) ]
CIPS [4 Certification Exam(s) ]
Cisco [270 Certification Exam(s) ]
Citrix [35 Certification Exam(s) ]
CIW [17 Certification Exam(s) ]
Cloudera [10 Certification Exam(s) ]
Cognos [19 Certification Exam(s) ]
College-Board [2 Certification Exam(s) ]
CompTIA [33 Certification Exam(s) ]
ComputerAssociates [6 Certification Exam(s) ]
CPP-Institute [1 Certification Exam(s) ]
CWNP [12 Certification Exam(s) ]
Dassault [2 Certification Exam(s) ]
DELL [7 Certification Exam(s) ]
DMI [1 Certification Exam(s) ]
ECCouncil [18 Certification Exam(s) ]
ECDL [1 Certification Exam(s) ]
EMC [122 Certification Exam(s) ]
Enterasys [13 Certification Exam(s) ]
Ericsson [5 Certification Exam(s) ]
Esri [2 Certification Exam(s) ]
ExamExpress [15 Certification Exam(s) ]
Exin [39 Certification Exam(s) ]
ExtremeNetworks [3 Certification Exam(s) ]
F5-Networks [19 Certification Exam(s) ]
Filemaker [9 Certification Exam(s) ]
Financial [35 Certification Exam(s) ]
Fortinet [10 Certification Exam(s) ]
Foundry [6 Certification Exam(s) ]
Fujitsu [2 Certification Exam(s) ]
GAQM [7 Certification Exam(s) ]
Genesys [4 Certification Exam(s) ]
Google [4 Certification Exam(s) ]
GuidanceSoftware [2 Certification Exam(s) ]
H3C [1 Certification Exam(s) ]
HDI [9 Certification Exam(s) ]
Healthcare [3 Certification Exam(s) ]
HIPAA [2 Certification Exam(s) ]
Hitachi [27 Certification Exam(s) ]
Hortonworks [1 Certification Exam(s) ]
Hospitality [2 Certification Exam(s) ]
HP [712 Certification Exam(s) ]
HR [1 Certification Exam(s) ]
HRCI [1 Certification Exam(s) ]
Huawei [20 Certification Exam(s) ]
Hyperion [10 Certification Exam(s) ]
IBM [1491 Certification Exam(s) ]
IBQH [1 Certification Exam(s) ]
ICDL [6 Certification Exam(s) ]
IEEE [1 Certification Exam(s) ]
IELTS [1 Certification Exam(s) ]
IFPUG [1 Certification Exam(s) ]
IIBA [2 Certification Exam(s) ]
IISFA [1 Certification Exam(s) ]
Informatica [2 Certification Exam(s) ]
Intel [2 Certification Exam(s) ]
IQN [1 Certification Exam(s) ]
IRS [1 Certification Exam(s) ]
ISACA [4 Certification Exam(s) ]
ISC2 [6 Certification Exam(s) ]
ISEB [24 Certification Exam(s) ]
Isilon [4 Certification Exam(s) ]
ISM [6 Certification Exam(s) ]
iSQI [7 Certification Exam(s) ]
Juniper [54 Certification Exam(s) ]
Legato [5 Certification Exam(s) ]
Liferay [1 Certification Exam(s) ]
Lotus [66 Certification Exam(s) ]
LPI [21 Certification Exam(s) ]
LSI [3 Certification Exam(s) ]
Magento [3 Certification Exam(s) ]
Maintenance [2 Certification Exam(s) ]
McAfee [8 Certification Exam(s) ]
McData [3 Certification Exam(s) ]
Medical [25 Certification Exam(s) ]
Microsoft [228 Certification Exam(s) ]
Mile2 [2 Certification Exam(s) ]
Military [1 Certification Exam(s) ]
Motorola [7 Certification Exam(s) ]
mySQL [4 Certification Exam(s) ]
Network-General [12 Certification Exam(s) ]
NetworkAppliance [35 Certification Exam(s) ]
NI [1 Certification Exam(s) ]
Nokia [2 Certification Exam(s) ]
Nortel [130 Certification Exam(s) ]
Novell [37 Certification Exam(s) ]
OMG [9 Certification Exam(s) ]
Oracle [232 Certification Exam(s) ]
P&C [1 Certification Exam(s) ]
Palo-Alto [3 Certification Exam(s) ]
PARCC [1 Certification Exam(s) ]
PayPal [1 Certification Exam(s) ]
Pegasystems [10 Certification Exam(s) ]
PEOPLECERT [4 Certification Exam(s) ]
PMI [15 Certification Exam(s) ]
Polycom [2 Certification Exam(s) ]
PostgreSQL-CE [1 Certification Exam(s) ]
Prince2 [6 Certification Exam(s) ]
PRMIA [1 Certification Exam(s) ]
PTCB [2 Certification Exam(s) ]
QAI [1 Certification Exam(s) ]
QlikView [1 Certification Exam(s) ]
Quality-Assurance [7 Certification Exam(s) ]
RACC [1 Certification Exam(s) ]
Real-Estate [1 Certification Exam(s) ]
RedHat [8 Certification Exam(s) ]
RES [5 Certification Exam(s) ]
Riverbed [8 Certification Exam(s) ]
RSA [13 Certification Exam(s) ]
Sair [8 Certification Exam(s) ]
Salesforce [3 Certification Exam(s) ]
SANS [1 Certification Exam(s) ]
SAP [78 Certification Exam(s) ]
SASInstitute [15 Certification Exam(s) ]
SAT [1 Certification Exam(s) ]
SCO [9 Certification Exam(s) ]
SCP [6 Certification Exam(s) ]
SDI [3 Certification Exam(s) ]
See-Beyond [1 Certification Exam(s) ]
Siemens [1 Certification Exam(s) ]
Snia [6 Certification Exam(s) ]
SOA [15 Certification Exam(s) ]
Social-Work-Board [1 Certification Exam(s) ]
SUN [63 Certification Exam(s) ]
SUSE [1 Certification Exam(s) ]
Sybase [17 Certification Exam(s) ]
Symantec [132 Certification Exam(s) ]
Teacher-Certification [3 Certification Exam(s) ]
The-Open-Group [8 Certification Exam(s) ]
TIA [3 Certification Exam(s) ]
Tibco [18 Certification Exam(s) ]
Trend [1 Certification Exam(s) ]
TruSecure [1 Certification Exam(s) ]
USMLE [1 Certification Exam(s) ]
VCE [5 Certification Exam(s) ]
Veeam [2 Certification Exam(s) ]
Veritas [25 Certification Exam(s) ]
Vmware [51 Certification Exam(s) ]
Wonderlic [1 Certification Exam(s) ]
XML-Master [3 Certification Exam(s) ]
Zend [5 Certification Exam(s) ]
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